منابع مشابه
Dmd059204 1627..1639
The contribution of drug metabolites to the pharmacologic and toxicologic activity of a drug can be important; however, for a variety of reasons metabolites can frequently be difficult to synthesize. To meet the need of having samples of drug metabolites for further study, we have developed biosynthetic methods coupled with quantitative NMR spectroscopy (qNMR) to generate solutions of metabolit...
متن کاملGenis , Planning Resources 1586
Thank you for the opportunity to comment upon the Preliminary Draft Amendments to the Guidelines for the Implementation of the California Environmental quality Act (CEQA)(Title 14, California Code of Regulations). The Amendments are proposed in order to implement Senate Bill 97 (Dutton), which directs the Governor’s Office of Planning and Research (OPR) to develop guidelines for the mitigation ...
متن کاملDmd058289 1575..1586
Inhibition of cytochromes P450 by time-dependent inhibitors (TDI) is a major cause of clinical drug-drug interactions. It is often difficult to predict in vivo drug interactions based on in vitro TDI data. In part 1 of these manuscripts, we describe a numerical method that can directly estimate TDI parameters for a number of kinetic schemes. Datasets were simulated for Michaelis-Menten (MM) and...
متن کاملDev117150 1639..1650
Regulation of lumen growth is crucial to ensure the correctmorphology, dimensions and function of a tubular structure. How this is controlled is still poorly understood. During Ciona intestinalis notochord tubulogenesis, single extracellular lumen pockets grow between pairs of cells and eventually fuse into a continuous tube. Here, we show that lumen growth exhibits a lag phase, during which th...
متن کاملFamille de méthodes : la flexibilité au cœur du processus de construction de méthode
Situational Method Engineering (SME) was missing its rendezvous with industry mainly because of the complexity of proposed solutions and the need for advanced method engineering skills to apply them in practice. Today, SME is looking for new ways to facilitate situation-specific method construction. The inspiration comes from Software Product Line Engineering (SPLE), which is developing solutio...
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ژورنال
عنوان ژورنال: Revue d'histoire de l'Amérique française
سال: 1963
ISSN: 0035-2357,1492-1383
DOI: 10.7202/302253ar